Inhibition of gammaherpesvirus replication by RNA interference.
نویسندگان
چکیده
RNA interference (RNAi) is a conserved mechanism in which double-stranded, small interfering RNAs (siRNAs) trigger a sequence-specific gene-silencing process. Here we describe the inhibition of murine herpesvirus 68 replication by siRNAs targeted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic viral gene expression program, and open reading frame 45 (ORF 45), a conserved viral protein. Our results suggest that RNAi can block gammaherpesvirus replication and ORF 45 is required for efficient viral production.
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عنوان ژورنال:
- Journal of virology
دوره 77 5 شماره
صفحات -
تاریخ انتشار 2003